ACtiF NIHR Programme Grant

Development and evaluation of an intervention to support Adherence to treatment in adults with Cystic Fibrosis (ACtiF)

A UK-wide consortium of Cystic Fibrosis clinicians and researchers, led by Dr Martin Wildman of Sheffield Teaching Hospitals and Professor Alicia O’Cathain at the School of Health and Related Research, University of Sheffield, and the CF Trust, has been awarded a prestigious Programme Grant for Applied Research from the National Institute of Health Research to develop and evaluate new ways to support people with CF in their adherence to treatment. For further details visit the University of Sheffield weblink (click here).


  1. To embed adherence measurement in routine Cystic Fibrosis care by (i) building the IT infrastructure to capture adherence data from nebulisers (ii) developing a web-portal ‘cfhealthhub’ to display adherence data to people with Cystic Fibrosis (PWCF) and clinicians, and (iii) co-producing the web-portal interface with patients and clinicians to facilitate maximum utility.
  2. To develop a BCI that uses Feedback of measured adherence data, linked to a range of evidence based interventions including Problem Solving and Implementation Plans to increase adherence.
  3. To test the cost effectiveness of the BCI by (i) exploring its feasibility and acceptability in a mixed methods study, (ii) testing its efficacy in an RCT of 550 patients in 10 CF Units, (iii) understanding its implementation in practice using a process evaluation, and (iv) modelling its cost effectiveness.

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Prestigious NIHR Programme Grant awarded to Sheffield cystic fibrosis research team
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